Yu-qing LIU, Ai-shuai WANG, Shan JIANG, et al. Mechanism of Prunellae Spica on Non-small Cell Lung Cancer Based on Network Pharmacology. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(24):159-165(2019)
DOI:
Yu-qing LIU, Ai-shuai WANG, Shan JIANG, et al. Mechanism of Prunellae Spica on Non-small Cell Lung Cancer Based on Network Pharmacology. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(24):159-165(2019) DOI: 10.13422/j.cnki.syfjx.20192024.
Mechanism of Prunellae Spica on Non-small Cell Lung Cancer Based on Network Pharmacology
To explore the mechanism of Prunellae Spice in the treatment of non-small cell lung cancer (NSCLC) based on the network pharmacological method
in order to elaborate its scientific connotation.
Method:
2
The active ingredients and targets of Prunellae Spice were obtained through retrieval of the Traditional Chinese Medicine Integrated Database (TCMSP)
the disease-genome association database (DisGeNET) was searched to obtain the disease targets relating to non-small cell lung cancer
and the drug-component-disease-target network was constructed. The mechanism of action was analyzed. The key target protein-protein interaction (PPI) network was constructed. The gene ontology (GO) classification and enrichment analysis of key targets and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were carried out.
Result:
2
Totally 11 active ingredients and 178 targets were obtained from TCMSP
2019 genes relating to non-small cell lung cancer were obtained from DisGeNET database
114 key targets for Prunellae Spice to treat non-small cell lung cancer were obtained from drug-component-disease-target network
and 114 PPI networks were constructed
including 114 nodes and 1 952 edges. According to the analysis of PPI network
the key targets of Prunella vulgaris in the treatment of non-small cell lung cancer included protein kinase B (Akt)1
vascular endothelial growth factor(VEGFA)
Caspase-3
interleukin(IL)-6
JUN
mitogen-activated protein kinases(MAPK)8
MYC
epithelial growth factor receptor(EGFR). The enrichment of KEGG involved 152 biological processes
p53 signaling pathway and EGFR signaling pathway played key roles in the occurrence
development
invasion and metastasis of non-small cell lung cancer.
Conclusion:
2
This study preliminarily verified the basic pharmacological effect and mechanisms of Prunellae Spice on NSCLC
and laid a foundation for further exploring its mechanisms.
关键词
夏枯草非小细胞肺癌网络药理学活性成分作用机制
Keywords
Prunellae Spicenon-small cell lung cancernetwork pharmacologyactive ingredientsmechanism of action
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