黄芪、黄连、黄芩对核素心血池显像左室功能的作用

黄伟民; 严桦; 严建; 金洁美; 蔡瑾; 徐华元

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黄芪、黄连、黄芩对核素心血池显像左室功能的作用

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- 黄芪、黄连、黄芩对核素心血池显像左室功能的作用
- Effects of Astragalus Mcmbranaceus,Coptis Chinensis and Scutellaria Balicalensis on Left Ventricular Function Determined by Radionuclide Cardiac Blood-pool Imaging
- 中国实验方剂学杂志 1996年2卷第1期页码：32-35
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  中图分类号： R285.5
- 纸质出版日期：1996
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黄伟民, 严桦, 严建, 等. 黄芪、黄连、黄芩对核素心血池显像左室功能的作用[J]. 中国实验方剂学杂志, 1996,2(1):32-35.

Huang Weimin, Yan Hua, Yan, et al. Effects of Astragalus Mcmbranaceus,Coptis Chinensis and Scutellaria Balicalensis on Left Ventricular Function Determined by Radionuclide Cardiac Blood-pool Imaging[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(1): 32-35.
黄伟民, 严桦, 严建, 等. 黄芪、黄连、黄芩对核素心血池显像左室功能的作用[J]. 中国实验方剂学杂志, 1996,2(1):32-35. DOI：

Huang Weimin, Yan Hua, Yan, et al. Effects of Astragalus Mcmbranaceus,Coptis Chinensis and Scutellaria Balicalensis on Left Ventricular Function Determined by Radionuclide Cardiac Blood-pool Imaging[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(1): 32-35. DOI：

摘要

将黄芪、黄连、黄芩三昧中药联合组方

制成三黄合剂和心脉胶囊。用单光子发射型计算机断层(SPECT)核素心血池扫描观察三黄合剂或心脉胶囊对在心室功能的作用。静脉注射三黄合剂能明显提高犬左心室射血分数(LVEF)33.7%(p＜0.05)

缩短相角程(LPH)15.7%(p＜0.05)。但是临床上给陈旧性心肌梗塞患者口服心脉胶囊均无明显变化。对引起动物实验与临床效果不同的可能原因进行了讨论。

Abstract

Astragalus membranaceus

Coptis chinensis and scutellaria baicalensis were mixed and extracted with boiling water. The decoction is named Sanhuang Mixture(SHM)and its capsulized preparation called Xinmai Capsule(XMC).The effects of SHM or XMC on left ventricLilar function were observed with single photon ernission computerized tomograpl1y(SPECT) of radionuclide cardiac blood-pool imaging. SHM intravenously given significantly increased the left ventricular ejection fraction(LVEF) by 33.7%(P＜0.05) and shortened the left ventricular phase width(LPH) by 15.7%(P＜0.05) in canine. As for patients with old myocardial infarction

two week treatment with XMC did not significantly change LVEF

peak filling rate(PFR) and LPH. The possible reasons of the quite different restilts between canine and patient were discussed.

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