The Mechanism of Dual-Directional Thermoregulation by“Guizhi Tang”(桂枝汤Decoction of CinnamonTwigs)---Effect on the Action of Acetylcholine and Norepinephrine in Hypothalamus
Fu Hangyu, Guo Shuying, Gao Yingjie, et al. The Mechanism of Dual-Directional Thermoregulation by“Guizhi Tang”(桂枝汤Decoction of CinnamonTwigs)---Effect on the Action of Acetylcholine and Norepinephrine in Hypothalamus[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(2): 8-10.
Fu Hangyu, Guo Shuying, Gao Yingjie, et al. The Mechanism of Dual-Directional Thermoregulation by“Guizhi Tang”(桂枝汤Decoction of CinnamonTwigs)---Effect on the Action of Acetylcholine and Norepinephrine in Hypothalamus[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(2): 8-10.DOI:
After 20ng norepinephrine administered intracerebroventriculary(icv)
the body temperature of rats was rapidly dropped and 15 minutes later
minmized and the value of the area under the body temperature-time curve in 0.67 hours(TRI0.67)was -0.92±0.26. The hypothermic action of norepinephrine was inhibited by 10g/kg Guizhi Tang per os
with TRI0.67) being -0.50±0.10(P<0.01).1mg of Acetycholine icv was observed to cause hyperthermia.The peak was reached in 2 hours
and TRI3.0 was 1.25±0.52. Guizhi Tang p.o.could
on the other hand
bolck hyperthermia reaction induced by acetylcholine and the TRI3.0) was 0.34±0.49(P<0.01).The evidence indicated that Guizhi Tang could promoted degradation of excessive norepinephrine or acetycholibne in hypothalamus.