Liu Chenghai, LiuCheng, Liu Ping, et al. Effect of Sera Containing Fuzheng Huayu(FZHY) Decoction on Ito Cell Proliferation and Collagen Synthesis in Rats[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(2): 16-19.
Liu Chenghai, LiuCheng, Liu Ping, et al. Effect of Sera Containing Fuzheng Huayu(FZHY) Decoction on Ito Cell Proliferation and Collagen Synthesis in Rats[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(2): 16-19.DOI:
Using a serum pharmacological method that the sera
derived from the rats orally taking FZHY
were incubated with culturd ito cells(Fat-storing cells
passage 1) of the rats
it wasinvestigated that FZHY affected ito cell functions such a cell proliferation and collagen synthesi.The results showed that the FZHY sera had no cytotoxicity towards the ito cells inhibited cell proliferation and collagen synthesis.Furthermore
this inhibition had a positive relation with administration and dosage of the FZHYdecoction bood-taken tine
and the concentration of the sera in the culture
was concluded that the inhibition of FZHY on ito cells may be one of mechanisms through which liver fibrosis was prevented with it.