As con1pared with non-dosed controls

the liver of the rats treated with Fuzheng Huayu recipe or Yangyin Rougan recipe was observed to display obvious decrease in the number of hyperplastic zones in the hepatocytes during the precarcinoma period. Also

activities of GGT and GST in the liver and serum ALP were markedly reduced.In the 24th week after the rats was treated bV diethylnitrosamine(DEN) for induction of hepatocarcinoma

the incidence of hepatocarcinoma was 100%in the control

while 92.9%and 85.7%

respectively

in the groups treated with the two recipes.And the lower activities of GGT and GST in the live and serum ALP were also found.Yangyin Rougan recipe appeared to be more potent than the other one in preventing the cancer

The findings from hepatocyte cycle kinetics suggested that the two Chinese recipes were able to inhibit synthesis of hepatocyte DNA

leading to interruption of the cell division and proliferation.