方药配伍对“温补肾阳方”君药补骨脂有效成分煎出的影响

苏子仁; 刘庆思; 徐必达; 许龙桥; 毛旭升

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方药配伍对“温补肾阳方”君药补骨脂有效成分煎出的影响

更新时间：2024-01-04

- 方药配伍对“温补肾阳方”君药补骨脂有效成分煎出的影响
- Influence of the Drug Compatibility on the Active Principle Extraction of Fructus Psoraleae in the Formuk for Warming and Tonifying Kidney-Yang
- 中国实验方剂学杂志 1996年2卷第5期页码：8-12
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家中医药管理局资助95B137
- DOI：
  中图分类号： R289.1
- 纸质出版日期：1996
- 稿件说明：
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苏子仁, 刘庆思, 徐必达, 等. 方药配伍对“温补肾阳方”君药补骨脂有效成分煎出的影响[J]. 中国实验方剂学杂志, 1996,2(5):8-12.

Su Ziren, Liu Qingsi, Xu Bida, et al. Influence of the Drug Compatibility on the Active Principle Extraction of Fructus Psoraleae in the Formuk for Warming and Tonifying Kidney-Yang[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(5): 8-12.
苏子仁, 刘庆思, 徐必达, 等. 方药配伍对“温补肾阳方”君药补骨脂有效成分煎出的影响[J]. 中国实验方剂学杂志, 1996,2(5):8-12. DOI：

Su Ziren, Liu Qingsi, Xu Bida, et al. Influence of the Drug Compatibility on the Active Principle Extraction of Fructus Psoraleae in the Formuk for Warming and Tonifying Kidney-Yang[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(5): 8-12. DOI：

摘要

选用L12(211)正交表

通过薄层扫描法

测定补骨脂素、异补骨脂素的含量

研究温补肾阳方中各药与补骨脂的配伍变化。结果显示

调配处方时

将补骨脂捣碎使用

可显著增加有效成分的煎出

温补肾阳方的补骨脂与健脾药大枣、黄芪合用

可显著提高补骨脂有效成分的煎出

白芍、丹参、当归、菟丝子可显著增加有效成分的煎出

而制首乌、熟地具有降低有效成分煎出的趋势。实验结果揭示中医方药“相使”配伍的内在物质基础。

Abstract

The changes of the content of psoralen and isopsoralen in the formula for tonifying kidney-yang were determined by orthogonal test

L12(211)

and thin-layer chromatography. The results showed that the extracted elements of Fructus Psoraleae(FP)was markedly increased by pounding before decocted.In case the FP was decocted together with the Fructus ujubae and Radix Astragali(drugs for strengthening the spleen)

the extracted elements of FP are also increased markedly. The experiment also showed that the extracted elements of FP are markedly increased when decocted together with Radix Paeoniae Alba

Radix Salviae Miltiorrhizae

Radix Angelicae Sinensis and Semen Cucustae

but a tendency of decrease by decocted with Radix Polygoni Multiflori and Radix Rehmanniae Preparata. These findings revealed the inherent basis ofthe principle of compatibility is“Mutual promoting”.

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