大承气汤介导肝脏、胆汁、血浆灭活内毒素的实验研究

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- 大承气汤介导肝脏、胆汁、血浆灭活内毒素的实验研究
- Experimental Study on Inactivating LPS of Liver,Bile,and Plasma Mediated by Dachengqi Decoction
- 中国实验方剂学杂志 1997年3卷第1期页码：15-18
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  中图分类号： R-33
- 纸质出版日期：1997
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田在善, 李东华, 沈长虹, 等. 大承气汤介导肝脏、胆汁、血浆灭活内毒素的实验研究[J]. 中国实验方剂学杂志, 1997,3(1):15-18.

Tian Zaishan, Li Donghua, Shen Changhong, et al. Experimental Study on Inactivating LPS of Liver,Bile,and Plasma Mediated by Dachengqi Decoction[J]. Chinese journal of experimental traditional medical formulae, 1997, 3(1): 15-18.
田在善, 李东华, 沈长虹, 等. 大承气汤介导肝脏、胆汁、血浆灭活内毒素的实验研究[J]. 中国实验方剂学杂志, 1997,3(1):15-18. DOI：

Tian Zaishan, Li Donghua, Shen Changhong, et al. Experimental Study on Inactivating LPS of Liver,Bile,and Plasma Mediated by Dachengqi Decoction[J]. Chinese journal of experimental traditional medical formulae, 1997, 3(1): 15-18. DOI：

以鲎试剂定量测定法进行的体内、外实验证实:去芒硝大承气汤、胆盐对LPS有直接灭活效应;正常大鼠经口投予大承气汤（DT）后

其血浆对外加LPS灭活能力增强;经口投予DT于肠源性内毒素血症（EETM）模型大鼠后

肝组织血流量（ml/100g/min）和肝胆汁流率增加

其肝胆汁对外加LPS的灭活能力增强。

In this study

Dachengqi Decoction without Mirabilite and bile salts was observed to have direct inactivating effect on LPS

which was measured by Tachypleus Amebocyte Lysate quantitative test in vitro.when normal rats were administered with DT orally

the inactivating ability of the plasma on LPS was increased.When DT was administered to the model rats with enterogenous endotoxemia(EETM)

the heptic regional blood flow(ml/100g/min)

bile flow and the bile inactivating ability on LPS has been improved greatly.

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