醒脑康制剂对动物中枢缺氧和脑循环的作用

王明正1; 梁月琴1; 顿文1; 武冬梅1; 李晓敏1; 牛拴成1; 张慧芳2; 程金虎3

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醒脑康制剂对动物中枢缺氧和脑循环的作用

更新时间：2024-01-04

- 醒脑康制剂对动物中枢缺氧和脑循环的作用
- Effects of Xingnaokang Formula on the Cerebral Anoxia and Circulation in Animals
- 中国实验方剂学杂志 1997年3卷第2期页码：20-23
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R-332
- 纸质出版日期：1997
- 稿件说明：
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王明正1, 梁月琴1, 顿文1, 等. 醒脑康制剂对动物中枢缺氧和脑循环的作用[J]. 中国实验方剂学杂志, 1997,3(2):20-23.

Effects of Xingnaokang Formula on the Cerebral Anoxia and Circulation in Animals[J]. Chinese journal of experimental traditional medical formulae, 1997, 3(2): 20-23.
王明正1, 梁月琴1, 顿文1, 等. 醒脑康制剂对动物中枢缺氧和脑循环的作用[J]. 中国实验方剂学杂志, 1997,3(2):20-23. DOI：

Effects of Xingnaokang Formula on the Cerebral Anoxia and Circulation in Animals[J]. Chinese journal of experimental traditional medical formulae, 1997, 3(2): 20-23. DOI：

摘要

采用大鼠、小鼠脑缺氧模型观察了醒脑康制剂对其中枢缺氧的耐受性影响

并以电磁流量计测定了醒脑康提取液对犬脑循环的作用。结果表明

醒脑康可显著延长大、小鼠脑缺血性缺氧后的存活时间和夹闭大鼠气管后的脑电活动时间。iv给药

能明显扩张犬脑血管、降低脑血管阻力

增加脑血流量。在产生作用初期

可降低犬心肌张力—时间指数

并具有短暂的降压作用

但对动物心率无明显影响。

Abstract

Effect of Xingnaokang formula(XNKF)on cerebral tolerance to anoxia was studied in rats and mice.The effects of XNKF on cerebral circulation were also examined by electromagnetic flow meter in dogs.The findings revealed that XNKF(6.0、12.0g/kg ig)significantly prolonged the survival time of the animals with cerebral ischimia anoxia and the lasting time of cerebral electrical activities in rats after their tracheae were blocked XNKF extraction(10.0、20.0g/kg iv)can also dilate the cerebral blood vessels

decrease the resistance of cerebral blood vessels

and increase the flow of cerebral blood in dogs.In the primary period of its action

XNKF extraction can lower the myocardial tension-time index steadily and the blood pressure temporarily

but no effect on heartbeat in dogs.

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