通络熄风注射液对脑缺血再灌注大鼠脑血氧代谢及血压的影响

郭改会; 李宁章; 酒谷熏; 董鸿瑞; 庄逢源; 傅仁杰; 左焕琮

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通络熄风注射液对脑缺血再灌注大鼠脑血氧代谢及血压的影响

更新时间：2024-01-04

- 通络熄风注射液对脑缺血再灌注大鼠脑血氧代谢及血压的影响
- Effect of Tongluoxifeng on the Metabolism of Cerebral Oxygenation and BloodPressure During Cerebral Ischemia-reperfusion in the Rats
- 中国实验方剂学杂志 1998年4卷第1期页码：21-24
- 作者机构：
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  中图分类号： R285.5
- 纸质出版日期：1998
- 稿件说明：
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郭改会, 李宁章, 酒谷熏, 等. 通络熄风注射液对脑缺血再灌注大鼠脑血氧代谢及血压的影响[J]. 中国实验方剂学杂志, 1998,4(1):21-24.

Guo Gaihui, Li Ningzhang, Kaoru SAKATANI, et al. Effect of Tongluoxifeng on the Metabolism of Cerebral Oxygenation and BloodPressure During Cerebral Ischemia-reperfusion in the Rats[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(1): 21-24.
郭改会, 李宁章, 酒谷熏, 等. 通络熄风注射液对脑缺血再灌注大鼠脑血氧代谢及血压的影响[J]. 中国实验方剂学杂志, 1998,4(1):21-24. DOI：

Guo Gaihui, Li Ningzhang, Kaoru SAKATANI, et al. Effect of Tongluoxifeng on the Metabolism of Cerebral Oxygenation and BloodPressure During Cerebral Ischemia-reperfusion in the Rats[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(1): 21-24. DOI：

摘要

应用近红外线血氧测定仪非侵入性地观察了通络熄风注射液对脑缺血再灌注大鼠脑血氧代谢的影响

结果:缺血期脑组织氧合血红蛋白[HB.O2]及总血红蛋白[HB.T]明显低于缺血前

而还原血红蛋白[HB]则明显增高;再灌注后HB.O2及HB.T均升高超过缺血前水平

继而再降低

生理盐水组降低的幅度明显大于通络熄风注射液组

而HB在再灌注后先降低而后升高

两组升高的幅度无显著差异。

Abstract

We studied the effect of Tongluoxifeng on the metabolism of cerebral oxygenation and blood pressure during cerebral ischemia-reperfusion in the rats by noninvasive near infrared spectroscopy .The results showed that oxyhaemoglobin [HB.O2] & total haemoglobin [HB.T] in the brain tissure decreased after ischemia;but deoxyhaemoglobin [HB] increased after ischemia.After reperfusion

both HB.O2& HB.T returned to the control and exceeded the control

and then decreased again.The reduction of HB.O2 & HB.T after reperfusion in normal saline group was significantly larger than that in Tongluoxifeng group.These results indicated that Tongluoxifeng could prevent the reduction of cerebral blood flow during reperfusion.

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