Liu Chenghai, Liu Ping, Liu Cheng, et al. Study on a Seropharmacological Method for an Effective Antifibrotic Formula[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(2): 16-19.
Liu Chenghai, Liu Ping, Liu Cheng, et al. Study on a Seropharmacological Method for an Effective Antifibrotic Formula[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(2): 16-19.DOI:
The serum was collected from rats fed on Fuzheng Huayu (FZHY) decoction
and FZHY decoction was lyophilized into powder. And both were incubated with hepatic stellate cells (HSC) and hepatocytes. Then cell morphology and functions were observed to study the seropharmacological methods for antifibrotic traditional Chinese herbs. The results showed that the FZHY powder inhibited cell proliferation and viability. The deactivated rat's sera drawn 1h after FZHY-treatment twice had no cytotoxity
promoted hepatocyte proliferation
and inhibited HSC proliferation. Therefore
this seropharmacological method could be applied for antifibrotic herbal formulae.