Xue Baoyun, Ye Zuguang, Dai Baoqiang, et al. Study on Antimalarial Activity of Qinghaosu in Combination with Sulfa Drugs[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(3): 17-19.
Xue Baoyun, Ye Zuguang, Dai Baoqiang, et al. Study on Antimalarial Activity of Qinghaosu in Combination with Sulfa Drugs[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(3): 17-19.DOI:
The anti-recrudescent effects of Qinghaosu(QHS)in combination with sulfa drugs were studied in mice infected with Plasmodium berghei.Results showed that the combinations of QHS 100~400 mg/kg with Sulfadiazine(SD) or Sulfadoxine(SDM′) could eliminate recrudescence of Plasmodium berghei or postpone the interval between parasitemia clearance and its recrudescence. When QHS dose was increased up to 400 mg/kg
all the combinations with different sulfa drugs could delay reappearance of the parasites in the blood
although antimalarial potency of the sulfa drugs varied.