Xu Baoyu, Xie Daozhen, Shi Dazhuo, et al. The Effect of Naoxie Shutong Oral Liquid on P53 and HSP70 Gene Expression in Brain Tissue in Rats with Experimental Vascular Dementia[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(4): 33-36.
Xu Baoyu, Xie Daozhen, Shi Dazhuo, et al. The Effect of Naoxie Shutong Oral Liquid on P53 and HSP70 Gene Expression in Brain Tissue in Rats with Experimental Vascular Dementia[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(4): 33-36.DOI:
The in situ hybridization and biomedical image pattern analysis were applied in this experiment to examine P53 mRNA and HSP70 mRNA expression level in vascular dementia (VaD)of brain tissue in rats with MID produced by injecting paraffin oil to left ventricle.The result showed that Naoxie Shutong oral liquid(NXST)can improve the expression of HSP70 mRNA by diminishing the expression of P53 mRNA
leading to accelerating recovery and protecting the ischemic neuron of brain tissue.