ZHOU Li-ling, LIU Qiang, LI Rui. Selection of Transdermal Enhancers for Sinomenine in PVA Layer[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(5): 3-5.
ZHOU Li-ling, LIU Qiang, LI Rui. Selection of Transdermal Enhancers for Sinomenine in PVA Layer[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(5): 3-5.DOI:
the selection of transdermal enhancers for sinomenine from various proportion of azone
propylene glycol and oleic acid was studied using improved Franz cell for equipment of absorption study
pH 6.8 phosphate buffer as absorption solution
skin of hairless mice as experimental skin
HPLC for measuring the content of sinomenine.Result:the transdermal speed constant of sinomenine was the hgihest while the contents of azone and propylene glycol is 6% and 10%
respectively.The result indicates that a certain proportion of azone and propylene glycol can improve transdermal absorption of sinomenine.