Objective:To investigate the influence of artesunate（ART） on invasion and apoptosis of novel human palatal salivary gland cell line of adenoid cystic carcinoma（NACC）.Method: After treated with ART 100 mg · L-1

apoptosis cells were observed after loaded with acridine orange/ethidium bromide dye（AO/EB）.The anti-invasion effect of ART at 25

50

100 mg · L-1 were examined by transwell assay.The expression of vascular endothelial growth factor（VEGF） and its mRNA of NACC cells was evaluated by immunohistochemistry and RT-qPCR technique separately.Result:①Compared with the control group

apoptosis cells were observed after treated with ART 100 mg · L-1

with irregular and shrinked nucleolus;②The result of transwell assay showed that ART at 25

50

100 mg · L-1 could inhibit the transmembrane cells obviously compared with control group（P<0.01）;③Compared with the control group

the VEGF protein expression decreased obviously after stimulated with ART（P<0.01）;④Same result were observed in VEGF mRNA expression by RT-qPCR（P<0.01）.Conclusion: ART could induce apoptosis

decrease VEGF expression and invasion of NACC cells in vitro.