Objective:To study inhibitory activity of raw products and five processed products of Psoralea corylifolia for α-glucosidase.Method: With acarbose as positive control

inhibitory activity was screened by α-glucosidase in vitro inhibitory model.Result: Each parts from raw and processed products of P.corylifolia had some α-glucosidase inhibitory activity

and the activity of them were higher than acarbose.Methanol total extracts of salt steamed P.corylifolia

fried salt P.corylifolia and fried P.corylifolia showed higher inhibitory activity（IC50=23.03

31.26

36.06 μg·L-1

respectively） than methanol total extract of raw P.corylifolia（IC50=46.47 μg·L-1）.Petroleum ether extracts of salt steamed P.corylifolia and tripterygium wilfordii method P.corylifolia had higher inhibitory activity（IC50=17.96

34.02 μg·L-1

respectively） than petroleum ether extracts of raw P.corylifolia（IC50=46.94 μg·L-1）.Acetic ether extracts of five processed products（salt steamed P.corylifolia

tripterygium wilfordii method P.corylifolia

fried salt P.corylifolia

fried P.corylifolia ang wine fried P.corylifolia） had higher inhibitory activity（IC50=51.27

39.08

40.86

45.54

36.06 μg·L-1

respectively） than acetic ether extracts of raw P.corylifolia（IC50=71.28 μg·L-1）.n-Butyl alcohol extacts of salt steamed P.corylifolia and wine fried P.corylifolia showed higher inhibitory activity（IC50=47.52

36.06 μg·L-1

respectively） than n-butyl alcohol extacts of raw P.corylifolia（IC50=51.27 μg·L-1）.In addition

the inhibitory activity of each parts extracts was positively correlated with the mass concentration

that was in a concentration dependent manner.Conclusion: Raw products and five processed products of P.corylifolia exhibited certain α-glucosidase inhibitory activity.