Objective:To study anti-inflammatory and analgesic effect of water extract of Sauropus rostratus.Method: The LD50level of the water extract was determined by modified Karber’s method.Dimethylbenzene-induced auricle edema in mice

carrageenan-induced hind paw edema in rats and cotton ball-induced granuloma in mice were respectively performed to investigate the anti-inflammatory effect of the extract（14

7

3.5 g · kg-1）.Mouse twisting numbers induced by acetic acid and mouse pain threshold after heat stimulation on hot-plate tests were respectively performed to investigate the analgesic effect of S.rostratus.Result:The LD50level of water extract of S.rostratus.was 68 g · kg-1

the auricle edema induced by dimethylbenzene in mice

catton ball-induced granuloma in mice and carrageenan-induced hind paw edema in rats were inhibited significantly by water extract of S.rostratus.（P<0.05 or P<0.01）

water extract of S.rostratus could remarkably reduce mouse twisting numbers（P<0.05 or P<0.01）

but could not improve pain threshold.Conclusion:The water extract of S.rostratus had anti-inflammatory effect and analgesic effect

the researches could provide a scientific basis for developing and utilizing of S.rostratus.