Objective:To study effect of different technologic extracts from shengzhi Yingyang fang on renal function poisoned by adenine in mice.Method: One hundred SPF grade male healthy mice were randomly divided into 5 groups

which were the control group

the model group

Shengzhi Yingyang Fang 1 group（water extraction）

Shengzhi Yingyang Fang 2 group（75% alcohol）

Shengzhi Yingyang Fang 3 group（40% alcohol）.The models were established by orally giving adenine to the mice at 300 mg · kg-1 and at the same time

3 experimental groups were orally given different technologic extracts from sheng zhiyingyang fang decoctum（crude drugs at 1.96 g · kg-1）

five times a week for 2 months.Result: Shengzhi Yingyang fang significantly decreased（P<0.05）the contents of creatinine（SCr）

urea nitrogen（BUN）

lactic acid（LD） and the activity of xanthine oxidase（XOD）in plasma.Furthermore

it could significantly reduce（P<0.05） the activities of acid phosphatase（ACP） and alkaline phosphatase（AKP） and improve（P<0.05）the activities of succinodehydrogenase（SDH） of renal tissue poisoned by adenine in mice.The effect of water extraction is the best.Conclusion: Different technologic extracts from shengzhi Yingyang fang decoctum have protective effects on renal function poisoned by adenine

among which the effect of water extract is the best.