Objective:To investigate the effect of saikosaponin a（SSa） on expression of multidrug resistant protein P-glycoprotein（P-gp） in refractory epilepsy rats induced by licl-pilocarpine.Method: Except for the blank control group（A）

thirty SD refractory epilepsy rats were randomly divided into 5 groups

namely

sodium valproate（VPA） group C（200 mg · kg-1

ig）

low

middle and high dose of SSa group（0.54

1.09

2.18 mg · kg-1

ip）.The model group（B） and group A received the same amount of saline.At the end of treatment for 8 weeks

the expression of P-gp in rat hippocampus and temporal lobe cortex was detected by Western blotting.Result: The P-gp expressed in the rat hippocampus and temporal cortex in different groups had statistically significant difference（P<0.001）.Compared with group A

the expression of P-gp were increased significantly in the other groups（P<0.05）;the expression was increased in group C（P<0.05）

but decreased in group D

E and F when compared with group B.The reduction of expression was most apparent in group E（P<0.05）.Conclusion:SSa can reduce the expression of P-gp in hippocampus and temporal cortex with a slightly dose-dependent manner

which may be one of the anticonvulsant mechanisms of SSa.