Objective:To investigate the effects of Zingiber officinale carbo on coagulation function and thromboxane B2（TXB2）

6-keta-prostaglandin F1α（6-keto-PGF1α） in asthenia cold and blood deficiency syndrome Rats.Method: Eighty SD rats were randomly divided into 8 groups: normal control

model

small

medium and large dose groups of Z.officinale carbo.The model of asthenia cold was made by oral administration of rhubarb for 10 days.After 6 days of model

the normal control group and the model group were ig given normal saline.Z.officinale carbo groups were given the Z.officinale carbo decoction at different doses（10

20

40 g · kg-1） daily for 5 days.Blood deficiency syndrome was made by the orbit blooding method.1 h after lasting administration

blood samples were collected to detect the serum levels of thrombin time（TT）

prothrombin time（PT）

activated thromboplastin time（APTT）

fibrinogen（FIB）

d-dimer（D-D） and TXB2/6-keto-PGF1α were observed.Result: Z.officinale carbo could effectively shorten TT（P<0.05）

PT（P<0.05）

APTT（P<0.05）

increase the contents of FIB（P<0.01）

and decrese the contents of D-D（P<0.05）

increase the level of TXB2（P<0.01） and decrease the level of 6-keto-PGF1α（P<0.01）.Conclusion: The mechanism of Z.officinale carbo may affect the coagulation and the level of TXB2 and 6-keto-PGF1α.