Objective:To observe effect of astragalosides extract on liver fibrosis in rats.Method: Sixty SD rats were randomly divided into six groups: normal control group（A）

model group（B）

colchicine group（C）

low-dose astragalosides group（D）

middle-dose astragalosides group（E） and high-dose astragalosides group（F）.Liver fibrosis model in rat was produced with bovine serum albumin（ABS）.Group C received colchicine（0.1 mg · kg-1 · d-1）;group D

E

F received low-dose astragalosides（15 mg · kg-1 · d-1）

middle-dose astragalosides（30 mg·kg-1·d-1） and high-dose astragalosides（60 mg · kg-1 · d-1） ig respectively.After 55 days

serum levels of serum total protein（TP）

albumin（ALB）

alanine aminotransferase（ALT）

aspartate aminotransferase（AST）

hyaluronic acid（HA）

laminin（LN）

type Ⅲ procollagen（PC-Ⅲ） and type Ⅳ collagen（Ⅳ-C） in different groups were detected.Result: Compared with model group

levels of ALT

AST

HA

LN

PC-Ⅲand Ⅳ-C in the treatment groups were obviously improved.It had significantly statistical difference（P<0.05

P<0.01）.Pathological result showed that the liver fibrosis in the treatment groups was signiflcantly attanuated.Conclusion: These results suggested that astragalosides shows obvious effect against rat hepatic fibrosis.