Objective: To investigate influence of Zhikeqing capsule on blood inflammatory factors in patients with hyperlipidemia. Method: Ninty-five patients with hyperlipidemia were randomly divided into treatment group of 47 cases and control group of 48 cases.Another 15 healthy cases were established as the normal control.The treatment was given oral Zhikeqing capsule 3 capsules tid; control group was received simvastatin 20 mg daily (all for 8 weeks).Blood lipid levels were determined and the enzyme-linked immunosorbent assay (ELISA) method was used for the determination of high sensitive C-reactive protein (hs-CRP)

interleukin-6 (IL-6)

von Willebrand factor (vWF) and homocysteine (Hcy). Result: After treatment

the differences in TC

TG and HDL-C between the two groups with the normal controls were not significant; however LDL-C in the two groups was higher than that in the normal control group (P<0.05

P<0.01)

and the treatment group was better than the control group (P<0.05).After treatment hs-CRP and IL-6 in control group were higher than those of the normal control group (P<0.01); in the treatment group

hs-CRP and IL-6 were lower than those of the control group (P<0.05) and without significant difference to the normal controls.After treatment

vWF and Hcy in treatment group and the control group showed no significant difference with the normal controls. Conclusion: Zhikeqing capsule can regulate lipid metabolism

adjust inflammatory factor

so as to reduce arterial stiffness index.