Objective: To explore the effects of reformatted Linggui Zhugan decoction on metabolic syndrome. Method: Seventy male specified-pathogens free (SPF) Wistar rats

aged 3 weeks

were divided into seven groups in randomized manner: control group treated with distilled water diet; high fat (49% lard) and high salt (4% NaCl

model group); high fat and salt group treated with atovastatin (lipid-lowering group); high fat and salt group treated with metformin (hypoglycemic group); high fat and salt group treated with reformatted Linggui Zhugan decoction large dose

middle dose and small dose groups.The rats of these groups were taken in high fat and high salt except control group.And rats of each group were administrated by gavge at the same time once every day for 8 weeks.Among them

lipid-lowering group rats were given 8 mg·kg-1 atovastatin; hypoglycemic group rats 670 mg·kg metformin; reformatted Linggui Zhugan decoction large dose group

middle dose group and small dose group rats 18

12

6 g·kg-1 reformatted Linggui Zhugan decoction concentrated solution differently.Control group and model group rats were given normal salt administration by gavage equal content.The level of serum resistin

adiponectin and insulin were detected by enzyme-linked immunosorbent assay (ELISA).And insulin resistance (HOMA-IR) index was counted. Result: The level of resistin

adiponectin

insulin was of a very significant difference after reformatted Linggui Zhugan decoction were given for 8 weeks

compared with control group and model group (all P<0.01).The level of insulin and HOMA-IR index was not significantly difference compared with the control group

lipid-lowering group and hypoglycemic group

but there was a significant difference compared with the model group (all P<0.01). Conclusion: The reformatted Linggui Zhugan decoction can regulate metabolic syndrome

adiponectin

insulin and HOMA-IR index.It is suggested that reformatted Linggui Zhugan decoction have effect on regulation fat and saccharide metabolism.