Objective: To study the effect of compound Wuguteng capsule on tumor necrosis factor-α(TNF-α)

natural killer cell (NK) activity of in mice with Lewis lung cancer. Method: Fifty C57 BL/6 male mice of vaccination Lewis lung cancer were randomly divided into five groups within 24 hours

tumor-bearing control group

Cyclophosphamide group (CTX

0.02 g·kg-1)

Compound Wuguteng capsule large

medium and small dose groups (2.25

1.125

0.562 5 g·kg-1).give medicine

once a day

for 12 days

the next day after the last time given medicine

put to death mice

strip and weigh the neoplasm

calculate the tumor inhibition rate

take the spleen preparation splenic cell suspension liquid

detection of TNF-α

NK activity. Result: Tumor inhibiting rate of compound Wuguteng capsule 2.25

1.125 g·kg-1 dose group was 31.43% and 22.38%. Compared with tumor-bearing control group

TNF-α cytotoxic index (45.79±7.01)%

compound Wuguteng capsule 2.25

1.125 g·kg-1 dose group of cytotoxic index(60.48%±8.29) %

( 56.00±9.72)%

are significantly improved (P<0.01

P<0.05).Compared with tumor-bearing control group

NK cell kill rate(10.37±21.33)%

compound Wuguteng capsule 2.25

1.125

0.562 5 g·kg-1 dose group of NK cell kill rate(32.23±24.03)%

(35.22±12.67)%

(26.70±12.11)%

are significantly improved (P<0.01

P<0.05). Conclusion: Compound Wuguteng capsule has inhibitory effecton on tumor in mice with Lewis lung cancer

enhance TNF-α and NK activity so as to improve the immune function of mice tumor-burdened.