Objective: Based on rat adriamycin-caused model of nephritic syndrome (NS) by constant release technology using osmotic pump

to evaluate the efficacy of Zhenwu decoction on NS. Method: Osmotic pump filled with adriamycin (14.5 mg·kg-1) was implanted into rats enterocoelia

then induced the NS on rats by constant release of adriamycin with osmotic pump

and after intervention of Zhenwu decoction

the urine protein

blood pressure

serum lipid parameters

plasmaprotein

renal function indicators

and IgG expression in glomerulus were detected

which was to assess the establishment of model of NS rat and the efficacy of Zhenwu decoction on it. Result: The survival rate of rats with adriamycin-caused NS using osmotic pump was improved significantly

no rats died during experiment.The NS occurred in the rats of model group at second week after giving driamycin

and compared with control group

the urine protein on 24 h and blood pressure were increased significantly after model establishment

and blood lipid

as well as markedly decreased serum protein and renal hypofunction were detected(P<0.01). Compared with model group

the mental state

activity

food intake and hair colour of rats were observably improved after administrating lower and higher doses of Zhenwu decoction (24

12 g·kg-1·d-1)

and both doses were capable of significantly decreasing urine protein and blood pressure(P<0.01)

recovering rats serum protein level(P<0.05)

improving blood urea nitrogen(BUN) and serum creatinine(Scr) levels

decreasing the content of total cholesterol(TC) and triglycerides(TG) (P<0.01)

and the notably decreased IgG deposition in rats mesangial area. Conclusion: The stable model of rat with NS could be successfully established using constant release function of osmotic pump and after intervention with Zhenwu decoction

it showed the efficacy on improving NS from the aspects of decreasing the urine protein

increasing plasma protein level

relieving hypercoagulable state

the decline in contents of BUN and Scr and restoring glomerular structure.