Objective:To explore effect of Bixie Shenshi decoction combined with fluconazole on the complex type of vulvovaginal candidiasis(VVC) and the vaginal microbial ecology. Method: Ninety cases which met the inclusion criteria of complex VVC between June 2010 to December 2011 were divided into three groups:Each group of 30 cases: Western medicine group (group A)

oral fluconazole; traditional Chinese medicine group (group B)

oral Bixie Shenshi decoction

combination of Chinese and Western medicine group(group C): application with Chinese medicine combined with fluconazole.Observe the therapeutic effect of three groups of patients and the vaginal microbial ecology changes before and after medication

and follow-up relapse after treatment. Result: The cure rate and total effective rate of three groups were as folloes:A group 73.3%

83.3%;B group 6.7%

73.3%;C group 93.3%

100%

group C was compared with group A and group B (P<0.05)

group A and group B had differences.In group A and group C recurrence rate was 31.8% and 3.6%

respectively

the two groups had significant difference(P<0.01).Before treatment of vaginal microecological exception occurrence rate in group was A 83.3%

group B 76.7%

group C 73.3%

comparison between groups was no difference.In three groups othe microecological anomaly rate after treatment was as follows:group A 46.7%; group B 16.7%;group C 6.7%

and compared with before treatment there were significant differences. Conclusion : Bixie Shenshi decoction combined with fluconazole in treatment of complicated VVC has notable efficiency.