Objective: To investigate influence of Danshen injection (DI) on inflammatory indexes in patients of type 2 diabetes with vascular lesions of lower extremities. Method: Retrospective analysis was carried out for 80 patients admitted to our hospital from January 2006 to December 2011 with diabetic vascular lesion of lower limbs.Randomized

double-blind

double-dummy

positive drug parallel control method were used.According to the ratio of 1: 1 the patients were randomly divided into treatment group and control group with 40 cases in each group.The control group was given conventional therapy

while the treatment group was given DI combined with conventional therapy.Serum inflammatory factor C reactive protein (CRP)

interleukin 6(IL-6) levels in the two groups before and after treatment were analized.Meanwhile

another 40 cases of type 2 diabetics without lower extremity vascular disease as the non-treatment group were compared. Result: Serum CRP

IL-6 levels in patients of diabetes mellitus with vascular lesions in the lower extremities were significantly higher than those in diabetic patients without vascular lesions.Serum CRP

IL-6 levels after treatment were significantly lower than those in the treatment group (P<0.05). Conclusion: Inflammatory indexes in patients of type 2 diabetes with vascular lesions in lower extremities were increased significantly.DI intervention is effective for lowing the inflammatory indexes.