万通筋骨喷雾剂的体外经皮渗透效果考察

葛克亚; 杜茂波; 刘淑芝; 李曼玲; 康琛; 宋立华; 王洪珍; 李颖

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万通筋骨喷雾剂的体外经皮渗透效果考察

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- 万通筋骨喷雾剂的体外经皮渗透效果考察
- Investigation of Transdermal Permeation Effect of Wantong Jingu Sprays
- 中国实验方剂学杂志 2013年19卷第5期页码：1-3
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家科技重大专项重大新药创制项目(2009ZX09301-005-05)
- DOI：
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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葛克亚, 杜茂波, 刘淑芝, 等. 万通筋骨喷雾剂的体外经皮渗透效果考察[J]. 中国实验方剂学杂志, 2013,19(5):1-3.

GE Ke-ya, DU Mao-bo, LIU Shu-zhi, et al. Investigation of Transdermal Permeation Effect of Wantong Jingu Sprays[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 1-3.
葛克亚, 杜茂波, 刘淑芝, 等. 万通筋骨喷雾剂的体外经皮渗透效果考察[J]. 中国实验方剂学杂志, 2013,19(5):1-3. DOI：

GE Ke-ya, DU Mao-bo, LIU Shu-zhi, et al. Investigation of Transdermal Permeation Effect of Wantong Jingu Sprays[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 1-3. DOI：

摘要

目的: 考察万通筋骨喷雾剂的经皮渗透效果。方法: 以绿原酸为指标

采用垂直式改良Franz扩散池装置进行试验

HPLC测定含量。结果: 万通筋骨喷雾剂样品的透皮速率27.919 μg·cm-2·h-1

6 h内平均累积透过率13.53%;绿原酸喷雾剂的透皮速率6.636 μg·cm-2·h-1

6 h内平均累积透过率3.78%。结论: 万通筋骨喷雾剂的体外透皮行为符合零级方程

其经皮渗透效果优于绿原酸喷雾剂。

Abstract

Objective:To investigate transdermal permeation effect of Wantong Jingu sprays. Method: Modified Franz diffusion cell was applied to investigate in vitro transdermal absorption behavior of Wantong Jingu sprays

with the content of chlorogenic acid as index

which was determined by HPLC. Result: In six hours

accumulated transdermal rate of Wantong Jingu sprays and chlorogenic acid sprays were 13.53%

3.78%

respectively; Transdermal rate were 27.919

6.636 μg·cm-2·h-1

respectively. Conclusion: In vitro transdermal absorption behavior of Wantong Jingu sprays was in accordence with zero-level equation

its transdermal absorption effect was better than chlorogenic acid sprays.

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