Objective: To optimize prescription technology of nasturtium total flavonoids dispersible tablets. Method: Single factor test was used to investigate lubricants

fillers

adhesion agents and disintegration agents;With disintegration time as index

orthogonal test was used to optimize prescription technology of nasturtium total flavonoids dispersible tablets with quality of MC

PVPPXL-10

PEG 6000 and PVPPXL as factor. Result: Optimum prescription process was as following:with MC as fillers

PEG 6000 as lubricants

95% ethanol as adhesion agents

PVPPXL-10 and PVPPXL as disintegration agents;Dry cream powder of total flavonoids from Trollius chinensis 200 g(50%)

MC 148.48 g(37.12%)

PVPPXL-10 34.09 g(8.52%)

PVPPXL 11.36 g(2.84%)

PEG 6000 6.06 G(1.52%)

made of 1 000 tablets.Disintegration time of these prepared tablets were less than 3 min

tablet weight 0.4 g

tablets disintegrate within 3 min were through the 2nd sieve

uniformity qualified compliance. Conclusion: This prescription process was stable and feasible with good traceability

it could provide experimental basis for quality standard of nasturtium total flavonoids dispersible tablets.