Objective: The comparison in treatment of hypoglycemia and hyperlipemia by Zengye Tang prescription with Rehmanniae Radix Processed by different method in diabetes rats was performe. Method: The high fat diet and intraperitoneal injection (ip) streptozotocin (STZ) 35 mg·kg-1 was used to establish diabetic model.Three weeks later ig

weight

food intake

the amount of water

hypoglycemic and hyperlipemia were observe. Result: Fresh Rehmanniae Radix

Rehmanniae Radix and Rehmanniae Radix Processed of Zengye Tang water extraction

alcohol extract could significantly reduce food intake

the amount of water

oral glucose tolerance and triglyceride(TG)

radix Rehmanniae Radix of Zengye Tang water extraction also could significantly reduce total cholesterol (CHO) and increase high density lipoprotein (HDLC)

fresh Rehmanniae Radix Radix and Rehmanniae Radix alcohol extract could reduced CHO

and there is no significant differencein HDLC

Rehmanniae Radix preparata water extraction

alcohol extract had no significant difference compared with model group. Conclusion: Fresh Rehmanniae Radix and Rehmanniae Radix could reduce the hyperglycemic and hyperlipemia in diabetes rats

water extraction and alcohol extract have no significant difference.Rehmanniae Radix preparata water extraction

alcohol extract have no apparent effect. Rehmanniae Radix with different processed method have a great influence on the hyperglycemic and hyperlipemia.