Objective:To optimize preparation technology of arbutin sustained-release creams and investigate its in vitro release. Method: With average number of milk drops and creams uniformity as comprehensive evaluation index

orthogonal test was used to optimize preparation technology of arbutin sustained-release creams with emulsification temperature

emulsification time and stirring speed as factors;The content of arbutin was determined by HPLC

in vitro release and stability of arbutin sustained-release creams were investigated. Result: Optimum preparation technology was as following:emulsifying temperature 80 ℃

emulsifying time 20 min and stirring with 1 200 r·min-1 for 20 min

then stopped heating

and stirred with 500 r·min-1 until cooled.Prepared arbutin sustained-release creams showed obvious sustained-release effect and good stability. Conclusion: Optimized preparation technology was stable and feasible

prepared samples had good sustained-release effect

it was suitale for industrial production of arbutin sustained-release creams.