Objective:To compare efficiency of vacuum extraction and conventional extraction of Epimedium brevicornum. Method: Taking composite score of icariin and total flavonoids extraction rate as index

L9(34) orthogonal test was used to optimized vacuum extraction and conventional extraction technology of E. brevicornum

and extraction efficiency of them was campared. Result: Extraction efficiency of vacuum extraction was significantly better than that of conventional extraction

optimum vacuum extraction conditions were as followings:extracted 3 times with 10 times the amount of 60% ethanol at 50 ℃

20 minutes each time

vacuum degree 0.07 MPa;Optimum conventional extraction conditions were:extracted 3 times with 10 times the amount of 60% ethanol

1 h each time.Extraction effect of vacuum extraction 1 h and conventional extraction 3 h was equal

and yield of dry extract with vacuum extraction could be reduced by about 30% than that of conventional extraction. Conclusion: Vacuum extraction was superior to conventional extraction technology

and the former was effective and stable

it could be used for industrial production of E. brevicornum.