喉喑安片的干法制粒工艺优选

申楼; 余楚钦; 张坤水; 黄思玉

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喉喑安片的干法制粒工艺优选

更新时间：2024-09-23

- 喉喑安片的干法制粒工艺优选
- Optimization of Dry Granulation Technology for Houyin'an Tablets
- 中国实验方剂学杂志 2013年19卷第5期页码：46-48
- 作者机构：
- 作者简介：
- 基金信息：
  
  广东省中医药局课题(2010201)
- DOI：
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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申楼, 余楚钦, 张坤水, 等. 喉喑安片的干法制粒工艺优选[J]. 中国实验方剂学杂志, 2013,19(5):46-48.

SHEN Lou, YU Chu-qin, ZHANG Kun-shui, et al. Optimization of Dry Granulation Technology for Houyin'an Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 46-48.
申楼, 余楚钦, 张坤水, 等. 喉喑安片的干法制粒工艺优选[J]. 中国实验方剂学杂志, 2013,19(5):46-48. DOI：

SHEN Lou, YU Chu-qin, ZHANG Kun-shui, et al. Optimization of Dry Granulation Technology for Houyin'an Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 46-48. DOI：

摘要

目的: 优选喉喑安片的干法制粒工艺。方法: 采用L9(34)正交设计试验

选取轮轧压力、压轮转速、进料转速为考察因素

以多指标综合评分考察干法制粒的工艺条件;在25 ℃

90%RH条件下

考察制备的喉喑安片的引湿性。结果: 最佳干法制粒工艺为A1B3C3

即轮轧压力4 MPa

压轮转速30 r·min-1

进料转速20 r·min-1

第10 d的引湿试验平均增重1.5%。结论: 该制备工艺质量稳定

产品防潮性良好。

Abstract

Objective:To optimize dry granulation technology of Houyin'an tablets. Method: With wheel rolling pressure

wheel speed and feeding speed as investigation factors

L9(34) orthogonal test was used to optimize dry granulation technology conditions with muiti-index composite score as index;Under 25 ℃

90%RH conditions

hygroscopicity of prepared Houyin'an tablets was investigated. Result: Optimum dry granulation technology was A1B3C3

that was the wheel rolling pressure of 4 MPa

pressure wheel speed 30 r·min-1

feeding speed of 20 r·min-1.On the tenth day

average increased weight of Houyin'an tablets was 1.5% by hygroscopicity test. Conclusion: Quality of Houyin'an tablets was stable with good moisture resistance

which was prepared by optimized technology.

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