探索用离子色谱测法定玄明粉中硫酸钠的含量

甘盛; 韩婷; 施晓光; 吴超权

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探索用离子色谱测法定玄明粉中硫酸钠的含量

更新时间：2024-01-04

- 探索用离子色谱测法定玄明粉中硫酸钠的含量
- Study on Determination of Sodium Sulfate Content in Natrii Sulfas Exsiccatus by Ion Chromatography
- 中国实验方剂学杂志 2013年19卷第6期页码：158-160
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- 纸质出版日期：2013
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甘盛, 韩婷, 施晓光, 等. 探索用离子色谱测法定玄明粉中硫酸钠的含量[J]. 中国实验方剂学杂志, 2013,19(6):158-160.

GAN Sheng, HAN Ting, SHI Xiao-guang, et al. Study on Determination of Sodium Sulfate Content in Natrii Sulfas Exsiccatus by Ion Chromatography[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 158-160.
甘盛, 韩婷, 施晓光, 等. 探索用离子色谱测法定玄明粉中硫酸钠的含量[J]. 中国实验方剂学杂志, 2013,19(6):158-160. DOI：

GAN Sheng, HAN Ting, SHI Xiao-guang, et al. Study on Determination of Sodium Sulfate Content in Natrii Sulfas Exsiccatus by Ion Chromatography[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 158-160. DOI：

摘要

目的: 探索玄明粉中硫酸钠含量离子色谱法的测定条件并与《中国药典》一部所载含量测定法比较。方法: 采用DIONEX ICS-3000离子色谱仪、IonPac ASII-HC分离柱和35 mmol·L-1NaOH作为淋洗液

流速1.0 mL·min-1

进样量40 μL

选用DIONEX ASRS300 4-mm抑制器、电导检测器测定玄明粉样品中硫酸钠含量。结果: 在1.053～105.300 mg·L-1

硫酸钠浓度呈良好的线性(R2=0.999 7)

平均回收率为98.39%

RSD 0.26%。结论: 方法灵敏准确、可操作性强

比药典记载的玄明粉含量测定法简便、稳定

为药用玄明粉的质量控制提供了另一种迅速实用的检测方法。

Abstract

Objective: To study the condition of determination of sodium sulfate content in Natrii Sulfas Exsiccatus samples by ion chromatography and make a comparison with the assay method described in Ch.P

volume I. Method: The DIONEX ICS-3000 ion chromatograph was adapted and equipped with IonPacRRASII-HC analytical column

eluted by 35 mmol·L-1 of NaOH solution at a flux of 1.0 mL·min-1.Each injection volume was 40 μL

using DIONEX ASRS®300 4-mm suppressor

connected to the conductive detector to assay the content of sodium sulfate in Natrii Sulfas Exsiccatus samples. Result: In the interval between 1.053 and 105.300 mg·L-1

the concentration of sodium sulfate was in good linearity at R2 of 0.999 7.The mean recovery was 98.39% with the RSD 0.26%. Conclusion: The method is sensitive

accurate and operational

proved to be convenient and more stable respect to the assay method described in the Chinese pharmacopeia

appropriate to the rapid control for medicinal Natrii Sulfas Exsiccatus quality.

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