Refer to the related literature in recent 10 years

the properties

the preparation

drug entrapment

and the applications of the proniosmes were reviewed in this paper. The characters are gel and a dry free-flowing granular.Preparation methods are mainly slurry method

coacervation phase separation method and slow spray-coating method.Factors the drug entrapment rate are the type and content of surfactant

cholesterol and lecithin content and the pH of the hydration medium.Applied to difficult soluble drugs

nsaids

hormone drugs

antihypertensive drug

anti-inflammatory analgesic

cerebrovascular expansion medicine

antiallergic

etc. But the former research of pronisomes are mainly pauses in the laboratory stage

the mechanism of action and clinical treatment need further exploration.