To conduct a literature review and analysis on the influencing factors in the process of the preparation of freeze-dried liposomes. Using freeze-dried liposome as the subject term to collect literature on freeze-dried liposome preparation aspects in the Chinese academic literature library (CNKI)

according to its correlation cited 35 articles

and concluded and summarized the influencing factors during the preparation process. The kinds and dosage of protective agent

ways of pre-freezing and speed

the degree of vacuum

drying time

hydration medium and other factors will affect the quality of the freeze-dried liposomes. In the process of preparation of freeze-dried liposomes

a variety of factors must be taken into account to prepare liposomes of a high encapsulating rate

high stability and small particle size changes. Application of freeze-drying technology can prevent drug oxidation

prolong drug liposome guarantee period

and lay a solid foundation for the promotion and application of liposome drug.