Objective:To evaluate the efficacy of Yougui pill with decision rules model based on rough set

to explore the interactions and position of the Yin-tonifying herbs

the Yang-tonifying herbs and the edge herbs

and then to improve the compatibility of Yougui pill. Method: The rats were divided into 8 groups

ie normal group

model group of kidney-yang deficiency

the original prescription group and five prescription groups by uniform design of Yougui pill. T4

CORT and T values were detected respectively. The decision rules model based on rough set was set up. The interactions among the Yin-tonifying herbs

the Yang-tonifying herbs and the edge herbs were analyzed according to the decision rules. Result: There were synergies between the Yin-tonifying herbs and the Yang-tonifying herbs in Yougui pill. There were synergies between the edge herbs and the Yin-tonifying herbs. There were synergies between the edge herbs and the Yang-tonifying herbs when the amount of the Yang-tonifying herbs were small

while the edge herbs antagonistic with the Yang-tonifying herbs when the amount of the Yang-tonifying herbs were large in Yougui pill. Conclusion: The compatibility of Yougui pill should focus on benefiting both yin and yang

as well as mutual rooting of Yin-yang. The amount of the edge herbs was determined according to the amount of Yang-tonifying herbs in order to improve the efficacy of Yougui pill.