Box-Behnken设计优化黄芩超高压提取工艺

叶陈丽; 贺帅; 张守尧; 张忠义

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Box-Behnken设计优化黄芩超高压提取工艺

更新时间：2024-09-23

- Box-Behnken设计优化黄芩超高压提取工艺
- Optimization of Ultrahigh Pressure Extraction Technology of Baicalin from by Box-Behnken Design
- 中国实验方剂学杂志 2013年19卷第3期页码：40-44
- 作者机构：
- 作者简介：
- 基金信息：
  
  广东省自然科学基金项目(8151051501000054)
- DOI：
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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叶陈丽, 贺帅, 张守尧, 等. Box-Behnken设计优化黄芩超高压提取工艺[J]. 中国实验方剂学杂志, 2013,19(3):40-44.

YE Chen-li, HE Shuai, ZHANG Shou-yao, et al. Optimization of Ultrahigh Pressure Extraction Technology of Baicalin from by Box-Behnken Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 40-44.
叶陈丽, 贺帅, 张守尧, 等. Box-Behnken设计优化黄芩超高压提取工艺[J]. 中国实验方剂学杂志, 2013,19(3):40-44. DOI：

YE Chen-li, HE Shuai, ZHANG Shou-yao, et al. Optimization of Ultrahigh Pressure Extraction Technology of Baicalin from by Box-Behnken Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 40-44. DOI：

摘要

目的: 应用Box-Behnken试验设计优选黄芩的超高压提取工艺。方法: 以黄芩苷提取率为指标

采用单因素试验考察提取压力、提取次数、液固比等因素对黄芩超高压提取工艺的影响;Box-Behnken试验设计考察乙醇体积分数、液固比、提取压力对提取工艺的影响

优化工艺参数。结果: 最佳提取工艺条件为乙醇体积分数72%

提取压力100 MPa

液固比100∶1

提取时间10 s

黄芩苷提取率102.65 mg·g-1。结论: 优选的工艺提取率高、提取温度低、耗时短、能耗少

适用于黄芩的工业化提取。

Abstract

Objective:To optimize ultrahigh pressure extraction (UPE) process of baicalin from Scutellaria baicalensis by Box-Behnken design. Method: With yield of baicalin as index

influence of extraction pressure

extraction times

liquid-solid ratio and other factors on UPE of S. baicalensis was investigated by single factor test;Box-Behnken design was employed to optimize extraction technology parameters with ethanol concentration

liquid-solid ratio and extraction pressure as independent variables. Result: Optimum extraction technology conditions were as following:extracted 10 s with 100 times the amount of 72% ethanol by extraction pressure of 100 MPa

yield of baicalin was 102.65 mg·g-1. Conclusion: Optimized technology had higher yield

lower extracting temperature

shorter extacting time and less power consumption

it was suitable for industrial production of S. baicalensis.

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