HPLC测定小儿感冒丹中盐酸麻黄碱和盐酸伪麻黄碱的含量

王苏会; 闫荟; 孙晓迪; 张京; 王瑞; 孙世光

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HPLC测定小儿感冒丹中盐酸麻黄碱和盐酸伪麻黄碱的含量

更新时间：2024-01-04

- HPLC测定小儿感冒丹中盐酸麻黄碱和盐酸伪麻黄碱的含量
- Simultaneous Determination of Ephedrina Hydrochloridum and Pseudoephedrine Hydrochloride in Xiaoerganmaodan Patch by HPLC
- 中国实验方剂学杂志 2013年19卷第6期页码：145-147
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- 纸质出版日期：2013
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王苏会, 闫荟, 孙晓迪, 等. HPLC测定小儿感冒丹中盐酸麻黄碱和盐酸伪麻黄碱的含量[J]. 中国实验方剂学杂志, 2013,19(6):145-147.

WANG Su-hui, YAN Hui, SUN Xiao-di, et al. Simultaneous Determination of Ephedrina Hydrochloridum and Pseudoephedrine Hydrochloride in Xiaoerganmaodan Patch by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 145-147.
王苏会, 闫荟, 孙晓迪, 等. HPLC测定小儿感冒丹中盐酸麻黄碱和盐酸伪麻黄碱的含量[J]. 中国实验方剂学杂志, 2013,19(6):145-147. DOI：

WANG Su-hui, YAN Hui, SUN Xiao-di, et al. Simultaneous Determination of Ephedrina Hydrochloridum and Pseudoephedrine Hydrochloride in Xiaoerganmaodan Patch by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 145-147. DOI：

摘要

目的: 建立小儿感冒丹中盐酸麻黄碱和盐酸伪麻黄碱的含量测定方法。方法: 用HPLC对小儿感冒丹中盐酸麻黄碱和盐酸伪麻黄碱进行定量分析。结果: 盐酸麻黄碱的线性范围为0.120～0.600 μg(r=0.999 9)

平均加样回收率为100.80%

RSD 1.8%;盐酸伪麻黄碱的线性范围为0.148～0.740 μg(r=0.999 8)

平均加样回收率为99.12%

RSD 1.4%。结论: 所建立的方法简便、准确、专属性强、可用于控制该制剂的质量。

Abstract

Objective: This study is aimed to develop and validate a HPLC method for quantitative analysis of ephedrina hydrochloridum and pseudoephedrine hydrochloride in Xiaoerganmaodan Patch. Method: Phedrina hydrochloridum and pseudoephedrine hydrochloride were analyzed quantitatively by HPLC method. Result: A good linearity was obtained over the concentration range of 0.12-0.60 μg for ephedrina hydrochloridum (r=0.999 9)

and 0.148-0.740 μg for pseudoephedrine hydrochloride (r=0.999 8).The average recovery of ephedrina hydrochloridum was 100.8%(RSD 1.8%)

and the average recovery of pseudoephedrine hydrochloride was 99.12%(RSD 1.4%)

respectively. Conclusion: The results of the study showed that the HPLC method was simple

sensitive and selective.It is suitable for the quality control of this preparation.

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