Objective: To optimize ultrafiltration purification technology parameters of Coptis chinensis extract. Method: With extract rate

the content of berberine hydrochloride

coptisine

palmatine and epiberberine as indexes

influence of hollow-fiber membranes with relative molecular weight 5 000

10 000 and 20 000 on ultrafiltration purification technology of C. chinensis extract was investigated by single factor test;Temperature and concentration of sample liquid

sample flow rate were chosen as factors

orthogonal test was used to optimize ultrafiltration purification technology parameters of C. chinensis extract with composite score of integrated content and transfer rate of index components as an indicator. Result: Hollow-fiber membrane with 5 000 relative molecular weight had better separation efficiency as others

optimum ultrafiltration technology parameters were as followings:liquid temperature 40℃

liquid speed 40 mL·min-1

liquid concentration 25 g·L-1. Conclusion: Hollow-fiber membrane could be selectively used in purification of liquid

it could increase retention rate of active ingredient.