Objective: To explore the protective effects of Buyang Huanwu decoction on focal cerebral ischemia in rat. Method: One hundred and eight-nine SD rats were randomly divided into sham operation group

model group and Buyang Huanwu decoction group (n=63). One week after the regular feeding

cerebral ischemia animal models was established. Buyang Huanwu decoction was given 2 h after operation(the dose of 5 g·kg-1·d-1 ig 1 times per day).Each group was divided into three sub-groups namely 7 days after administration

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21 d three time points. neurological function and brain tissue morphological changes in each group at different time points were observe. Result: The infarction area and neurological score in Buyang Huanwu decoction group were significantly decreased compared with model group at the same time-phasep

the difference was statistically significant(P<0.05).Hippocampal and cortical cell morphology was significantly improved and cells were arranged neatly in Buyang Huanwu decoction group compared with the model group. Conclusion: Buyang Huanwu decoction can improve cerebral ischemic injury neurological recovery and tissue repair

has cerebral protective effect.