Objective:To optimize preparation technology of Changyan granule

and investigate its precipitation and molding technology. Method: Taking composite score of dry extract rate and berberine hydrochloride content as an indicator

orthogonal test was used to optimize extraction technology of Changyan granule with extraction time

extraction times and the amount of water as factors;Its precipitation technology was investigated by single factor test;With granule formability

mobility

hygroscopicity and pelletization as indexes

kinds of accessories were selected

and to determine the best moulding technology. Result: Optimum extraction technology was as following: decoction extracted 2 times with 10 times the amount of water

1.5 h per time;The concentration of alcohol precipitation of 60%;Optimal granulation technology was as following:the ratio of extract-icing sugar-dextrin 1: 2: 1

the critical relative humidity of61%. Conclusion: Optimized technologies of Changyan granule was stable and feasible

it could be applied to industrial production.