不同配比泽泻汤治疗痰浊型眩晕的量效关系研究

王艳梅; 武红莉; 程先宽; 王学勇; 荆志伟

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不同配比泽泻汤治疗痰浊型眩晕的量效关系研究

更新时间：2024-09-23

- 不同配比泽泻汤治疗痰浊型眩晕的量效关系研究
- Dose-effect Relationship among Zexie Decoction of Different Proportions in Treatment of Phlegm Vertigo
- 中国实验方剂学杂志 2013年19卷第5期页码：233-237
- 作者机构：
- 作者简介：
- 基金信息：
  
  中国中医科学院基本科研业务费自主选题项目(Z02154)
- DOI：
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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王艳梅, 武红莉, 程先宽, 等. 不同配比泽泻汤治疗痰浊型眩晕的量效关系研究[J]. 中国实验方剂学杂志, 2013,19(5):233-237.

WANG Yan-mei, WU Hong-li, CHENG Xian-kuan, et al. Dose-effect Relationship among Zexie Decoction of Different Proportions in Treatment of Phlegm Vertigo[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 233-237.
王艳梅, 武红莉, 程先宽, 等. 不同配比泽泻汤治疗痰浊型眩晕的量效关系研究[J]. 中国实验方剂学杂志, 2013,19(5):233-237. DOI：

WANG Yan-mei, WU Hong-li, CHENG Xian-kuan, et al. Dose-effect Relationship among Zexie Decoction of Different Proportions in Treatment of Phlegm Vertigo[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 233-237. DOI：

摘要

目的: 探讨不同配比泽泻汤治疗痰浊型眩晕的量效关系。方法: 采用高脂饲料喂养及颈部注射硬化剂建立痰浊眩晕模型

按照均匀设计原则将48只家兔分为正常组、模型组、泽泻汤配比1

3组和西比灵组

每组8只

3个泽泻汤配比组分别按5∶2(泽泻50 g

白术20 g)

1∶1(泽泻20 g

白术20 g)

1∶1(泽泻35 g

白术35 g)组方投药

均按煎剂6 g·kg-1·d-1 ig

2次/d

连续ig给药2周

10周后分别观察舌苔、眼震持续时间及颈动脉血液动力学。结果: 模型组比正常组体重明显增加(P<0.01)

出现厚腻舌苔

眼震持续时间明显变长(P<0.01)。与模型组相比

配比2组血清总胆固醇(TC)

低密度脂蛋白胆固醇(LDL-C)水平下降(P<0.05)

甘油三酯(TG)水平有更为明显的差异(P<0.01);配比1

3组TG

LDL-C水平均有极显著差异(P<0.01)。与配比2组相比

配比1

3组TG

LDL-C水平有统计学差异(P<0.05

P<0.01)。配比3组左侧椎动脉(LVA)的收缩期血流速度(Vs)、舒张期血流速度(Vd)、平均血流速度(Vm)较模型组加快(P<0.05)

其右侧椎动脉(RVA)的Vs

Vd和Vm较模型组明显加快(P<0.01)

基底动脉(BA)的Vs

Vm较模型组有明显加快(P<0.05或0.01)。与西比灵组比较

配比3组实验动物RVA

BA的Vd有明显加快现象(P<0.05)。结论: 泽泻汤不同配比均能调节血脂代谢

改善眩晕模型的眼震症状

其中1∶1(泽泻35 g、白术35 g)配比能获得优于其他配比组和西比灵组的疗效。

Abstract

Objective:To explore the dose-effect relationship among different ratio of Zexie decoction(ZD) on phlegm vertigo. Method: By feeding high fat diet and neck injection of sclerosing agent the phlegm vertigo model was established

according to the principle of uniform design 48 rabbits were divided into normal group

model group

ZD of 3 different ratio groups and flunarizine group

8 rats in each group

ratio of ZD was matched with groups respectively according to the 5∶2 (Zexie 50 g

Baizhu 20 g) 1∶1 (Zexie 20 g

baizhu 20 g)

1∶1 (Zexie 35 g

Baizhu 35 g) prescription medication

which were rally given for 2 weeks

10 weeks respectively after observation of tongue fur

nystagmus duration and carotid artery hemodynamics. Result: The weight in model group increased significantly compared with in the normal group(P<0.01)

appeared thick and greasy fur

nystagmus duration was significantly longer (P<0.01). Compared with the model group

cholesterol total(TC) of match group 2

decreased low density lipoprotein(LDL-C) level (P<0.05) and glycerin trilaurate(TG) level had more obvious difference (P<0.01); in match group 1 and 3 group TG

LDL-C levels had significant differences (P<0.01). And the ratio of the two groups was compared

match group 1 and 3 group TG

LDL-C level was statistically different (P<0.05

P<0.01). Systolic flow velocity(Vs)

diastolic flow velocity(Vd) and the average flow velocity(Vm) of Left vertebral artery(LVA) in match group 3 were faster than those in the model group (P<0.05)

speed up its Vs

Vd and Vm of right vertebral artery(RVA) than those in the model group (P<0.01)

significantly speeding up basilar artery(BA) velocity of the systolic wave (Vs)

diastolic peak velocity (Vd) and mean peak velocity (Vm) than those in the model group (P<0.05 or 0.01) was accelerated apparently. And flunarizine group

3 groups of experimental animal ratio of RVA

BA Vd have markedly were vaccelerated(P<0.05). Conclusion: ZD with different ratio can regulate lipid metabolism

improve nystagmus symptoms of vertigo model

1∶1 (Zexie 35 g

Baizhu 35 g) ratiohas a better effect.

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