Objective: To investigate absorption

distribution and elimination process of ZB-ISG in rabbits. Method: Study on pharmacokinetics of ZB-ISG and oral Zhibing solution (reference preparation) by double preparation and double-period method in New Zealand white rabbits

in vivo bioavailability of ZB-ISG was evaluated by determining the content of imperatorin in serum. Result: AUC of Zhibing solution and ZB-ISG were (610.89±36.09)

(1 150.77±64.6 1) μg· h· L-1

respectively

it showed that absorption degree of ZB-ISG in rabbits was higher than Zhibing solution.Cmax of Zhibing solution and ZB-ISG were (62.7±7.71)

(110.7±10.76) μg· L-1

respectively

tmax of Zhibing solution and ZB-ISG were (3.35±0.36)

(0.82±0.22) h

respectively

these showed that absorption amount and rate of imperatorin after nasal administration of ZB-ISG were higher than oral Zhibing solution. Conclusion: Comparing with oral Zhibing solution

ZB-ISG could greatly enhance bioavailability of imperatorin in rabbits.