Objective:To study the protect effects of Ganbao capsule on liver-injury induced by carbon tetrachlotide(CCl4)ethanol and acetaminophen in mice. Method: Sixty KM mice were divided into 6 groups randomly: blank control group

model group with liver injury

three experimental groups (Ganbao capsule 0.125

0.25

0.5 g·kg-1 respectively)

positive control group (biphenyl double ester 0.2 g·kg-1). CCl4

ethanol and acetaminophen were accordingly given to mice by oral gavage once in order to make the acute liver injury model at the end of experiment. Serum alanine aminotransferase (ALT)

aspartate aminotransferase (AST) and alkaline phosphatase (AKP) were measured

the liver index was simultaneously determined. In addition in CCl4-induced model

hemolysin

spleen and thymus indexes were measured. Result: Ganbao capsule high

middle dose could obviously reduce ALT

AST

liver index for the liver injury models(P<0.05 or P<0.01). High dose could reduce AKP's content in the mice model induced by acetaminophen(P<0.05)

and significantly increase hemolysin content in the CCl4 model

and reduce the thymus index and spleen index in the same model(P<0.05 or P<0.01). Conclusion: Ganbao capsule has the function of protecting the liver from liver injury induced by CCl4

ethanol and acetaminophen.