泽泻丹明饮对高脂血症大鼠血脂、脂联素水平的影响

洪军; 赵明芬; 汪建萍; 陈苗苗; 刘宏炳; 骆新; 安冬青

您当前的位置：

首页 >

文章列表页 >

泽泻丹明饮对高脂血症大鼠血脂、脂联素水平的影响

更新时间：2024-01-04

- 泽泻丹明饮对高脂血症大鼠血脂、脂联素水平的影响
- Influence of Zexie Danming Drink on Serum Lipids and Adiponectin in Rats with Hyperlipidemia
- 中国实验方剂学杂志 2012年18卷第24期页码：300-303
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金(81160429);新疆名医名方与特色方剂学实验室开放基金课题(XJDX0910-2009-01)
- DOI：
  中图分类号：
- 纸质出版日期：2012
- 稿件说明：
移动端阅览
洪军, 赵明芬, 汪建萍, 等. 泽泻丹明饮对高脂血症大鼠血脂、脂联素水平的影响[J]. 中国实验方剂学杂志, 2012,18(24):300-303.

HONG Jun, ZHAO Ming-fen, WANG Jian-ping, et al. Influence of Zexie Danming Drink on Serum Lipids and Adiponectin in Rats with Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 300-303.
洪军, 赵明芬, 汪建萍, 等. 泽泻丹明饮对高脂血症大鼠血脂、脂联素水平的影响[J]. 中国实验方剂学杂志, 2012,18(24):300-303. DOI：

HONG Jun, ZHAO Ming-fen, WANG Jian-ping, et al. Influence of Zexie Danming Drink on Serum Lipids and Adiponectin in Rats with Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 300-303. DOI：

摘要

目的: 观察泽泻丹明饮对高脂血症大鼠血脂、脂联素水平的影响。方法: 以高脂饮食喂养14 d建立高脂血症大鼠模型。分别以泽泻丹明饮高剂量生药(4.0 g·kg-1)、中剂量(2.0 g·kg-1)、低剂量(1.0 g·kg-1)及血脂康(20 mg·kg-1)进行干预

共21 d。监测血清甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL)和脂联素(ADP)水平

并在光镜下观察大鼠肝脏病理变化。结果: 泽泻丹明饮高剂量组与模型组比较

TG显著降低(P<0.01)

LDL-C明显降低(P<0.05)

HDL-C有升高趋势

血清ADP水平显著升高(P<0.01)。中剂量组与模型组比较血清ADP水平明显升高。结论: 泽泻丹明饮中、高剂量组可调节血脂、脂联素水平

具有良好的改善血脂紊乱作用。

Abstract

Objective:To observe the influence of Zexie Danming Drink (ZDD) on serum lipids and adiponectin in hyperlipidemic rats. Method: A high-fat diet was fed 14 d to establish rat model of hyperlipidemia. Rats in different groups were given drugs accordingly for 21 days: ZDD high dose (4.0 g·kg-1)

medium dose (2.0 g·kg-1)

low dose (1.0 g·kg-1) and Xuezhikang (20 mg·kg-1). Serum triglycerides (TG)

cholesterol (TC)

high density lipoprotein cholesterol (HDL)

low-density lipoprotein cholesterol (LDL)

and adiponectin factors (ADP) and liver pathological changes were determined and observed. Result: Compared with model group

TC and TG in ZDD high dose group were significantly lowered (P<0.01)

LDL-C decreased significantly (P<0.05)

serum ADP level increased significantly l (P<0.01) and with a trend of elevation in HDL-C

. Compared with model group

in the middle dose group serum ADP levelwas significantly increased. Conclusion: ZDD of high dose or medium dose can regulate blood lipids and adiponectin levels

with good improvement for dyslipidemia.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

脑心通胶囊对冠心病高脂血症患者脂联素及血管内皮功能的影响

血府逐瘀汤联合越鞠丸加减治疗稳定性心绞痛43例

茱萸丸治疗高脂血症痰浊阻遏证的临床疗效

茱萸丸治疗痰浊阻遏型高脂血症合并颈动脉粥样硬化的随机对照临床观察

基于肝脏代谢组学探究温胆汤干预ApoE^-/-高脂血症小鼠作用机制