Objective:To grope preparation technology of β-cyclodextrin(β-CD) inclusion compound of volatile oil in Guanxinkang capsule

in order to improve stability of volatile oil. Method: Inclusion complexes was prepared by saturated aqueous solution ultrasonic method

with inclusion rate of volatile oil

inclusion oil content and inclusion yield as comprehensive evaluation index

influence of ratio of β-CD and volatile oil

inclusion temperature and ultrasonic time on inclusion technology was investigated by central composite design

test data was fitted by multi-linear regression and binomial equation

inclusion technology conditions were optimized by response surface method

and to predictive analysis. Result: Optimum inclusion process conditions were as follows:ratio of β-CD and volatile oil of 7: 1

inclusion temperature at 45℃ and ultrasonic time of 40 min

deviation between observed and predicted values was less than 3%. Conclusion: Volatile oil was powdered and its stability had been increased after being included by β-CD.This optimized inclusion process was simple with high predictability

it could provide test basis for industrial production of Guanxinkang capsule.