Objective:To observe the influence of Jiawei Dachaihu decoction on experimental guinea pigs cholecystitis. Method: Fifty guinea pigs(weight between 350-450 g) subcutaneouslyinjected by Lincomycin Hydrochloride 60 mg·kg-1·d-1 everyday to establish cholecystitis model

were randomly divided into mdel

Jiawei Dachaihu decoction low

medium and high dose group

Xiaoyan Lidan tablets group and normal group. The control and model group were given 10 mL·kg-1 of distilled water by intragastric administration once everyday;Jiawei Dachaihu Tang low

medium and high dose group were given 3.83

7.67

15.33 g·kg-1 by intragastric administration different concentration decocting with 10 mL·kg-1

Xiaoyan Lidan tablets group was given corresponding concentration decocting with 0.25 g·kg-1 by intragastric administration

once everyday

administration for three weeks. Result: Jiawei Dachaihu decoction of medium and high dose can significantly increase the volume of bile(P<0.05)

also can significantly reducing the number of white blood cells in plasma(P<0.01). Jiawei Dachaihu decoction of low

medium and high dose can significantly decrease the content of tumor necrosis factor-α(TNF-α) and expression of TNF-α mRNA in animal gallbladder tissue(P<0.01

P<0.05). Conclusion: Jiawei Dachaihu decoction can increase volume of bile

reducing the number of white blood cells in plasma and decrease the content of TNF-α and expression of TNF-α mRNA in animal gallbladder tissue

which suggest there was a certain curative effect on cholecystitis.