Objective:To investigate the protective effect of Wuzi Yanzong decoction on experimental cryptorchidism mice. Method: Five-six weeks old BALB/c mice cryptorchidism was induced and divied into four groups as sham

model

low dose of Wuzi Yanzong decoction (100 mg·kg-1)

high dose of Wuzi Yanzong decoction (200 mg·kg-1). At the end of the study

testis tissues were collected for detection of testes weight

sperm density

live rate

histological structure changes of testis

detection intestes glutathione peroxidase(GSH-Px)

superoxide dismutase(SOD) activity and the malonyldialdehyde(MDA) content changes. Result: The Wuzi Yanzong decoction treated mice in the cryptorchid group significantly increased the mice testis weight (P＜0.01)

sperm density (P＜0.05)

sperm live rate (P＜0.01) and showed an improved histologic appearance. Wuzi Yanzong decoction treatment significantly increased the reduced SOD and GSH-Px enzyme activities (P＜0.05 or P＜0.01) and decreased the elevated tissue malondialdehyde (MDA) levels (P＜0.01) in testis tissues samples. Conclusion: Wuzi Yanzong decoction is a potential beneficial agent to reduce testicular damage in cryptorchid mice by decreasing oxidative stress.