Objective:To study the effect of dencichine injection on nervous system. Method: The rats were given drug by iv once daily for 7 consecutive days. The SD rats were divided into 4 groups randomly: normal saline(NS)group

the low dose group

middle dose group and high dose group

the effect of dencichine for injection on autonomic activities was observed after administration of 1

2 h

7 d and withdrawal of injection. The SD rats were divided into 5 groups randomly: normal saline (NS) group

the low dose group

middle dose group

high dose group and positive control group(7.5 mg·kg-1 Pentobarbital sodium)

the effect of dencichine for injection on concordant ability was observed after administration of 1 h

7 d and withdrawal of injection. Result: Dencichine injection at the dose of 135 mg·kg-1 reduced autonomic and concordant ability of rats

this phenomenon disappeared after stopping injecting drugs. Dencichine injection at the dose of 45 mg·kg-1 increased autonomic ability of rats

but the phenomenon disappeared soon

and the dose of 45 mg·kg-1 had no effect on the concordant ability. Dencichine for injection at the dose of 15 mg·kg-1 increase autonomic ability of rats in a short time after stopping injecting drugs

but it had no effect on the concordant ability. Conclusion: Dencichine injection at the dose of 135 mg·kg-1 has obvious effect on nervous system. Dencichine injection at the dose of 45 mg·kg-1 has excitatory effects on the nervous system in a short period of time. Dencichine for injection at the dose of 15 mg·kg-1 have no effect on the nervous system

which can be believed a safety dose.