Objective: Using genetically modified Kkay type 2 diabetic mice as the model

to observe the effect of Xinkaikujiang traditional decoction (XKKJ-group 1) and Xinkaikujiang Formula granules (XKKJ-group 2) for insulin sensitivity and blood lipids in KKay type 2 diabetic mice. Method: According to the blood sugar

thirty-six male KKay mice (10 weeks old) were randomly divided into 4 groups

including the model group

the rosiglitazone group (0.67 g·kg-1·d-1)

the XKKJ-group 1 and the XKKJ-group 2 (8.7 g·kg-1·d-1). The control group was consisted of 9 C57BL/6J male mice(10 weeks old). The treatment groups were administered orally once a day

and both the control group and model group were given 0.5% sodium carboxymethylcellulose (CMC) solution. After 4-week treatment

the random blood sugar

fasting blood sugar (FBG)

serum insulin and blood lipids were determined

and the insulin sensitivity index was calculated. Result: After 4-week treatment

compared with the control group

the model group's ISI was significantly lowered(P<0.01)

FBG

triglyceride (TG) and total cholesterol (TC) were increased significantly(P<0.01). Compared with the model group

ISI in XKKJ-group 1 and XKKJ-group 2 was significantly improved (P<0.01)

FBG significantly lowered(P<0.01)TG and TC lowed. There were no difference between XKKJ-group 1 and XKKJ-group 2. Conclusion: The Chinese medicine of XKKJ could improve the insulin resistance in KKay type 2 diabetes mice

increase insulin sensitivity and rnduce the blood sugar level

lipid levels. The efficacy is not related to the dosage form.